Suman Dalal

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EDUCATION

East Tennessee State University
Ph.D. in Biomedical Sciences (2015, Research work was done at ETSU)
Master of Philosophy in Zoology (2008)
M.Sc. in Zoology (2006)
B.Sc. in Zoology (2004)

FACULTY APPOINTMENTS

Assistant Professor, Dept of Health Sciences, ETSU (Aug. 2020- present)
Adjunct Faculty, Dept of Biomedical Sciences, ETSU (Sept. 2020- present)
Research Associate, Dept of Biomedical Sciences ETSU (Jan. 2016 – Aug.2020)
Research Assistant, Dept of Biomedical Sciences ETSU (Oct. 2013 – Dec. 2015)
Research Scholar, Dept of Biomedical Sciences ETSU (Oct. 2008 – Oct. 2013)

COURSES TAUGHT

HSCI 3020 Human Physiology
HSCI 2020/2021 Anatomy & Physiology II

RESEARCH FOCUS

Heart disease (HD) is the leading cause of death worldwide. Statistically, in the US, someone has a heart attack every 40 seconds. Therefore, there is an urgent need for novel therapeutics to attenuate the tremendous burden of HD on the health care system. My research work understands the molecular mechanisms involved in cardiac cells death and remodeling after a heart attack (ischemia-reperfusion injury) and identifies potential targets for preventing HD. The research work in my laboratory may help to spur the development of novel pharmaceuticals and therapeutic strategies for the treatment of HD. 

PUBLICATIONS

According to Google Scholar (07/08/2021), my research work has been cited 591 times and has a citation index of 14. My research gate score is 24.96.

Wingard M, Dalal S, Shook PL, Myers R, Connelly B, Thewke D, Singh M, and Singh K. Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet. Am J Physiol Heart Circ Physiol.; 320(6):H2324-H2338.PMID: 33929897

Dalal S, Shook LP, Singh M and Singh K (2020). Cardioprotective potential of exogenous ubiquitin. Cardiovasc Drugs Ther.; PMID: 32910339.

Dalal S, Daniels CR, Li Y, Wright GL, Singh M, Singh K (2020). Exogenous ubiquitin attenuates hypoxia/reoxygenation-induced cardiac myocyte apoptosis via the involvement of CXCR4 and modulation of mitochondrial homeostasis. Biochem Cell Biol.; 98(4):492-501. PMID: 31967865.

Scofield SLC, Dalal S*, Lim KA, Thrasher PR, Daniels CR, Peterson JM, Singh M, Singh K (2019). Exogenous ubiquitin reduces inflammatory response and preserves myocardial function 3 days post ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol.; 316(3):H617-H628, PMID: 30681370. * Co-first author with equal contribution. (Article published with an editorial; The role of ubiquitin in cardiac ischemia-reperfusion injury. Kobayashi M, Higa JK, Matsui T.Am J Physiol Heart Circ Physiol.;316(3):H583-H585 PMID: 30657725).

Scofield SLC, Daniels CR, Dalal S, Millard JA, Singh M, Singh K (2018). Extracellular ubiquitin modulates cardiac fibroblast phenotype and function via its interaction with CXCR4. Life Sci.; 211:8-16. PMID: 30195032.

Dalal S, Connelly B, Singh M, Singh K (2018). NF2 signaling pathway plays a pro- apoptotic role in β-adrenergic receptor stimulated cardiac myocyte apoptosis. PLoS One.;13(4): e0196626. PMID: 29709009.

Thrasher PR, Scofield SLC, Dalal S, Crawford CC, Singh M, Singh K (2018). Ataxia telangiectasia mutated kinase deficiency impairs the autophagic response early during myocardial infarction. Am J Physiol Heart Circ Physiol.;315(1):H48-H57. PMID: 29652546. (Article published with an editorial; Ataxia telangiectasia mutated kinase is an autophagic balancer at the onset of heart failure.Yoshioka J. Am J Physiol Heart Circ Physiol.;315(1):H80-H82 PMID: 29750568).

Daniel LL, Scofield, S.L.C., Thrasher, P.R., Dalal S, Daniels CR, Foster CR, Singh M, Singh K. (2016) Ataxia telangiectasia mutated kinase deficiency exacerbates left ventricular dysfunction and remodeling late after myocardial infarction. Am J Physiol Heart Circ Physiol.; 311(2):H445-52, PMID: 27288435.

Dalal S, Zha Q, Singh M, Singh K (2016). Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro- apoptotic protein BIK. Mol Cell Biochem.; 418(1-2):1-11, PMID: 27262843.

Singh M, Dalal S, Singh K (2014). Osteopontin: At the cross-roads of myocyte survival and myocardial function. Life Sci.; 118(1):1-6, PMID: 25265596 (review).

Dalal S, Zha Q, Daniels CR, Steagall RJ, Joyner WL, Gadeau AP, Singh M, Singh K (2014). Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors, mitochondrial death pathway, and endoplasmic reticulum stress. Am J Physiol Heart Circ Physiol.; 306(8):H1182-91, PMID: 24531809.

Steagall RJ, Daniels CR, Dalal S, Joyner WL, Singh M, Singh K (2014). Extracellular ubiquitin increases expression of angiogenic molecules and stimulates angiogenesis in cardiac microvascular endothelial cells. Microcirculation.; 21(4):324-32, PMID: 24308702.

Foster CR, Daniel LL, Daniels CR, Dalal S, Singh M, Singh K (2013). Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis. PLoS One.; 8(12):e83513, PMID: 24358288. (Article published with an editorial; Ataxia‐telangiectasia mutated kinase: A potential new target for suppressing inflammation in heart failure? Kukreja RC. J Am Heart Assoc. 2014 Dec; 3(6): e001591. PMID: 25520331.

Daniels CR, Foster CR, Yakoob S, Dalal S, Joyner WL, Singh M, Singh K (2012). Exogenous ubiquitin modulates chronic β-adrenergic receptor-stimulated myocardial remodeling: role in Akt activity and matrix metalloproteinase expression. Am J Physiol Heart Circ Physiol.; 303(12):H1459-68, PMID: 23042947.

Dalal S, Foster CR, Das BC, Singh M, Singh K (2012). β-adrenergic receptor stimulation induces endoplasmic reticulum stress in adult cardiac myocytes: role in apoptosis. Mol Cell Biochem.; 364(1-2):59-70, PMID: 22270541.

Singh M, Foster CR, Dalal S, Singh K (2010). Role of osteopontin in heart failure associated with aging. Heart Fail Rev.; 15(5):487-94, PMID: 20127409 (review).

Singh M, Roginskaya M, Dalal S, Menon B, Kaverina E, Boluyt MO, Singh K (2010). Extracellular ubiquitin inhibits beta-AR-stimulated apoptosis in cardiac myocytes: role of GSK-3beta and mitochondrial pathways. Cardiovasc Res.; 86(1):20-8, PMID: 20015977. (Article published with an editorial; Ubiquitin, a novel paracrine messenger of cardiac cell survival. Li, D., and Depre, C. Cardiovasc Res. 2010, 86:1-3; PubMed MID:20100704).

Singh M, Foster CR, Dalal S, Singh K. (2010) Osteopontin: role in extracellular matrix deposition and myocardial remodeling post-MI. J Mol Cell Cardiol.; 48(3):538-43, PMID: 19573532 (review).