Research
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Computational Modeling of Self-Assembled Nanoparticles for Drug and Gene Delivery
We develop computational frameworks for the predictive design of self-assembled nanoparticles, focusing on lipid nanoparticles and polymeric micelles for drug and gene delivery. Using generative AI and machine learning, we design ionizable lipids and LNP formulations and predict transfection efficiency and biodistribution, enabling strategies to reduce hepatic accumulation and enhance extrahepatic delivery. For polymeric micelles, we apply thermodynamic modeling to elucidate micelle formation mechanisms and enable predictive control over particle size and drug loading. Together, our work advances nanocarrier design from empirical optimization to rational, mechanism-driven engineering. -
Scalable Manufacturing of Nanomedicines for Solubilization, PK Control, and Precision Delivery
We develop scalable and reproducible manufacturing platforms for polymeric nanomedicines to address the poor aqueous solubility and limited clinical translation of many small-molecule therapeutics. Guided by thermodynamic and computational modeling, our work establishes GMP–compatible processes for producing drug-loaded polymeric micelles with consistent quality and performance. These platforms enable reliable encapsulation of diverse hydrophobic drugs while providing precise control over micelle size, drug loading, stability, and storage. Together, this work supports robust pharmacokinetic control and facilitates the clinical deployment of polymeric nanomedicines for precision drug delivery. -
Development of 3D Tissue Models for Drug Screening Applications
We develop three-dimensional tissue models to improve the physiological relevance of in vitro drug screening and efficacy testing. Our work applies tissue engineering principles to design scaffolds with tunable composition, architecture, and mechanical properties that better recapitulate native tissue microenvironments. Using diverse extracellular matrix components—including peptides, proteins, polysaccharides, and synthetic polymers—we engineer spatially patterned scaffolds capable of supporting complex multi-cellular interactions. Advanced fabrication strategies, such as microsphere sintering, freeze-drying, and additive manufacturing, enable precise control over scaffold geometry, porosity, and internal structure, facilitating more predictive and translatable 3D tissue models.